Ghurki entered politics in 2002 with the Pakistan People's Party (PPP) and became the first woman elected from a general seat in Lahore. She served as Federal Minister for Social Welfare, Special Education, Environment, and National Heritage. After losing her seat in 2013, she became president of the PPP Punjab Women Wing in 2017. In 2024, she secured a National Assembly seat through a reserved quota for women but faced temporary suspension due to legal disputes. She regained her seat later that year, continuing her political journey with the PPP.

Samina Khalid Ghurki was married to Khalid Javaid Ghurki, who also served as a member of the National Assembly, until his passing in 2011. The couple shared a deep commitment to both their family and their shared political endeavors, which played a significant role in shaping her path as a public figure. Ghurki is a devoted mother to two sons and two daughters, balancing her responsibilities as a parent with her impactful career in politics. Her dedication to her family, combined with her passion for public service, has been a hallmark of her life’s journey.